Don Whitley Hypoxystation Used in Lung Cancer Research

An article from the latest Don Whitley Newsletter

Originally posted here on June 25 by Deborah Robinson

Lung cancer is the most common cancer diagnosed in the world with an approximate figure of 1.6 million new cases diagnosed in 2008, 80% of which are comprised of non-small-cell lung cancer (NSCLC). Poor prognostic markers and delay in diagnosis account for a large segment of lung cancer cases to be past successful cure. Survival rates for this form of the disease are very low, with a 5-year survival rate of <9% (2010) of cases and <5.3% over 10-years (CRUK, public data). Lipid metabolism has been correlated to malignant progression and poor clinical outcome in NSCLC and has been suggested as a hallmark of cancer proliferation and a discriminating factor in treatment planning.

Dr Rosy Favicchio

Dr Rosy Favicchio

Dr Rosy Favicchio, at Imperial College London’s Comprehensive Cancer Imaging Centre, is researching the impact of lipid metabolism in cancer growth and is part of a team developing new diagnostic imaging technology that will help identify cancers based on their metabolic profile.

“We are directing precision medicine strategies by developing new diagnostic, prognostic and predictive biomarkers for patient stratification and early assessment to therapeutic response. If we are to use lipid metabolism as a reporter system for tumour metabolism and synthesize drugs that target the pathways regulating this particular aspect of tumour physiology, we need to generate data that accurately reproduce the tumour microenvironment. The ability to vary the hypoxic load in our model is fundamental for understanding the relationship driving lipid metabolic reprogramming. Our experiments using the Don Whitley Hypoxystation are designed to further our understanding of the role played by lipid metabolism under hypoxic conditions and evaluate its use as an effective biomarker and druggable driver of NSCLC malignant growth”.

For more information about the Don Whitley Hypoxystations click here: Don Whitley

To receive direct assistance about Don Whitley Hypoxystations in New Zealand Contact Anna

 

FAQ: PreSens Products

How Can You Do Oxygen Measurements in ppm?

PreSens oxygen sensors (like other sensors, e. g. electrodes) measure the partial pressure of oxygen. To get ppm you need the saturation cencentration of the system / solvent the sensor is used in. ppm calculated by the Fibox works for aqueous solutions only, according to:

100 % air saturation is 9 mg / 1000 g H2O (298 K) and 1 atm, i. e. 9 ppm

If the solubility  of oxygen in the solvent is considerably higher than in water, ppm at saturation in higher.

Do you have any other questions? Feel free to contact Anna.

Featured Product: Whitley Jar Gassing System

With the Whitley Jar Gassing System you can create perfect conditions for growing anaerobes in jars in just 2 minutes. This is particularly important for fastidious anaerobes.

  • Reduces the cost of creating microaerobic conditions by 98% and for anaerobic conditions by 89%. 
  • A full colour touch screen control panel allows you to monitor, in real time, that the criteria necessary for the creation of either anaerobic or microaerobic conditions has been met. 
  • It is easy to use so no complicated operator training is required. 
  • Incorporates PIN code protected user access levels for additional security. 
  • The optional printer enables you to create a hard copy audit trail for accreditation purposes. 

If you already have anaerobic jars that you wish to use you can order the adaptor kit, which will enable you to connect to your existing jars.

Watch videos and learn about specifications and accessories here: Jar Gassing System

If you are interested in learning more about this system, please contact Anna

PreSens New Product: Microx 4 and Microx 4 trace

Today we have the pleasure to introduce to you our brand new Microx 4 & Microx 4 trace! For the time being, it is the sole independent display controlled device on the market handling non-invasive and microsensors as well as sensor probes. Together with this stand-alone, portable fiber optic oxygen meters we present you two new sensor types: PSt7 for measurements in normal oxygen range (detection limit 15 ppb, 0 - 100 % oxygen) and PSt8 (detection limit 3 ppb, 0 - 10 % oxygen) for measuring oxygen traces.

PreSens will present the devices for the first time at the Analytica in Munich, April 1st - April 4th, 2014. The official start for sale will be on May 5th, 2014. But we will surely accept your orders beforehand.

Additionally, please note that we harmonized two of the technical specifications for hydroplates and hydrodishes. By next week we will also present new single-use flow through cells for oxygen and pH to our customers.

Would you like more information? Contact Anna.

Visit Don Whitley Scientific at Oxygen 2013

Following the success of the HypoxiaNet meeting in Essen last year, Don Whitley Scientific will be attending the next event – 8 to 12 June 2013 – in Oulu, Finland. With a host of international speakers lined up, the subject of this year’s meeting is ‘Dealing with hypoxia: regulatory aspects in cells, tissues and organisms‘ -

“Hypoxia can be life threatening – for cells and the organism. To adequately respond to the shortage of oxygen cells have to sense changes in their ambient oxygen concentration. How are changes in a physical parameter, i.e. the pO2, translated into a biological response such as modulation of gene expression?”

The aim of the meeting is to highlight and discuss the latest developments in the broad field of hypoxia response.  This is the second international congress arranged by the network following the Oxygen 2011 meeting in Davos, Switzerland.

The program of the 2013 meeting will include keynote lectures, short talks selected from submitted abstracts and a training school session.

Don Whitley Scientific will have a Hypoxystation at the meeting and our representatives: Fergus Murray (Product Engineering Manager), Sally Shelton (Export Manager) and Alun Kitsell (Export Sales) will be on hand to answer questions about the workstation.

For further details on the meeting or to book a place, please visit the event website.

DWS at Campylobacter, Helicobacter and Related Organisms (CHRO), 15 -19 September, Aberdeen

 Don Whitley Scientific (DWS) invites New Zealand customers to attend a workshop on Campylobacter ‘Omics technologies and their role in food safety’ in Hotel Monaco, Denver, Colorado (USA). The event will be run by Campylobacter, Helicobacter and Related Organisms (CHRO) on the 19th of May, 2013. 

Later this year, DWS will be attending the second workshop organised by the CHRO which is to be held  in the UK 15-19 September.  If you will be attending please be sure to say hello to DWS colleagues Dr Andrew Pridmore and Joe Walton.

Please contact Anna if you will be attending and would like to connect with DWS.

Welcome

Welcome to AS1 new and improved website. We will continually be making additional updates as well as doing our best to provide you with up-to-date news from our suppliers and clients.

Speaking of news, we would like to share our client’s news as it arises. If you have a press release or a story about your research or new applications and you would like us to post it on our site, please email us at annawilson@as1.co.nz.

Seeking a particular product but don’t see it here — please Contact Anna Wilson.

Dr. Barry Bochner to visit New Zealand

AS1 is pleased to announce, Dr. Barry Bochner will be presenting in New Zealand. Read his Biography and Presenting Schedule and contact Anna if you are interested in attending.

TITLE:  Phenotype MicroArrays: An Overview of the Technology and Applications

PRESENTER:  Barry R. Bochner, Ph.D., CEO & CSO, Biolog, Inc., Hayward, CA  Biography and New Zealand Presenting Schedule

Phenotype MicroArray (PM) technology allows a biologist to test thousands of phenotypes of a cell line in a single experiment, to gain a comprehensive overview of the metabolism, physiology, and pathway fluxes.It provides phenomic and metabolomic information that is complementary to genomic or proteomic analysis and often more easy to interpret and more useful.The PM technology platform is applicable to a wide range of cells including bacterial, fungal, or animal and enables metabolic analysis in the context of genotype-phenotype studies.  For example, it can be used for (1) analyzing cells with mutations to determine the metabolic and physiologic effects of genetic differences, (2) studying and defining cell metabolism and metabolic regulation, (3) understanding the interplay of environment and hormonal signals on cell metabolism and physiology, (4) optimizing cell culture conditions, and (5) looking at the effects of drugs and other chemicals on cellular pathways.  For microbial cells, recent work has demonstrated the utility of the technology for determining culture conditions that turn on and turn off production of toxins and other secondary metabolites that microbes can produce.  The technology also has many applications with human cells, including the assay of the effects of microbial toxins.  Specific examples and discoveries will be presented to illustrate the many uses of PM technology.